Tovar M R, Bremón A R, Gorricho B P, Mochales F B
Centro Nacional de Epidemiología, Instituto de Salud Carlos III, Sinesio Delgado 6, 28029 Madrid.
Rev Esp Quimioter. 1998 Mar;11(1):58-63.
The use of quinolones has increased remarkably in recent years. Monitoring the trends in the consumption of these antibiotics is essential for the assessment of bacterial resistance. Sales figures for this group of antibiotics for each province from 1985 through 1993 were obtained from the medication database at the Spanish Ministry of Health. The consumption in milligrams per inhabitant older than 15 were calculated for each province and year. Specific time trends in consumption for Spain were studied and provincial maps were made representing consumption in milligrams per person older than 15. Outpatient prescriptions of quinolones increased 155% between 1985 and 1993 in Spain, more than 2 tons per year. Seven of the eight provinces in Andalucia were among the ten provinces with greater consumption. A south-north pattern was detected from year to year. Important increases were observed in all the Spanish provinces. Further studies should consider this fact in the monitoring of antimicrobial resistance and should assess if provincial differences in consumption correlate with the prevalence of the infectious diseases treated with this group of antibiotics.
近年来喹诺酮类药物的使用显著增加。监测这些抗生素的消费趋势对于评估细菌耐药性至关重要。1985年至1993年期间每个省份这类抗生素的销售数据来自西班牙卫生部的药物数据库。计算了每个省份每年每15岁以上居民的毫克消费量。研究了西班牙消费的特定时间趋势，并绘制了省级地图，显示每15岁以上人均毫克消费量。1985年至1993年期间，西班牙喹诺酮类药物的门诊处方增加了155%，每年超过2吨。安达卢西亚八个省份中的七个是消费量较高的十个省份之一。逐年呈现出从南到北的模式。西班牙所有省份都出现了重要增长。进一步的研究在监测抗菌药物耐药性时应考虑这一事实，并应评估省份间的消费差异是否与用这类抗生素治疗的传染病患病率相关。
