Chrysis D, Moats-Staats B M, Underwood L E
Department of Pediatrics, Division of Endocrinology, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA.
J Endocrinol. 1998 Nov;159(2):R9-R12. doi: 10.1677/joe.0.159r009.
The insulin receptor-related receptor (IRR), a member of the insulin receptor tyrosine kinase family, has structural homology to the insulin receptor (IR) and the IGF-I receptor (IGF-IR). The ligand, gene regulation and biological function of the IRR are not known. Because mRNAs for both the IR and IGF-IR are increased by nutrient restriction, we used RNase protection assays to assess the effects of fasting 48 h on IRR mRNA in kidneys of rats. We compared the changes in IRR with those in IR and IGF-IR mRNAs. We observed a significant increase in steady state levels of IRR (ratio of IRR mRNA to beta-actin in fed P<0.01), suggesting that the ligand for IRR also might be regulated by nutrients.
胰岛素受体相关受体（IRR）是胰岛素受体酪氨酸激酶家族的成员，与胰岛素受体（IR）和胰岛素样生长因子I受体（IGF-IR）具有结构同源性。IRR的配体、基因调控和生物学功能尚不清楚。由于营养限制可使IR和IGF-IR的mRNA均增加，我们采用核糖核酸酶保护试验来评估禁食48小时对大鼠肾脏中IRR mRNA的影响。我们将IRR的变化与IR和IGF-IR mRNA的变化进行了比较。我们观察到IRR的稳态水平显著升高（喂食组中IRR mRNA与β-肌动蛋白的比值P<0.01），这表明IRR的配体也可能受营养物质的调控。
