委内瑞拉健康志愿者中耐抗生素粪便大肠杆菌的流行情况。
The prevalence of antibiotic-resistant faecal Escherichia coli in healthy volunteers in Venezuela.
作者信息
van de Mortel H J, Jansen E J, Dinant G J, London N, Palacios Prü E, Stobberingh E E
机构信息
Dept. of Medical Microbiology, University Hospital Maastricht, The Netherlands.
出版信息
Infection. 1998 Sep-Oct;26(5):292-7. doi: 10.1007/BF02962250.
Faecal samples were collected from healthy volunteers in two regions in Venezuela, the village of Grulla (n = 195) and the city of Mérida (n = 181), and analysed for the prevalence of antibiotic resistant faecal Escherichia coli as well as the antibiotic susceptibility of the strains isolated. The highest prevalences of resistance were observed for amoxicillin, oxytetracycline, sulfamethoxazole and trimethoprim. The percentages found for Grulla were 46, 38, 44 and 30%, respectively; for Mérida 39, 65, 56 and 36%, respectively. In Mérida, a significantly higher prevalence of resistance for oxytetracycline was found (P < 0.05). Significant differences in the distribution of the MIC values between Grulla and Mérida were observed for amoxicillin, chloramphenicol and oxytetracycline (P < 0.05). In Grulla, the most frequent pattern was resistance to amoxicillin only and in Mérida to oxytetracycline only. Amoxicillin resistance was due to production of TEM1 beta-lactamase.
从委内瑞拉两个地区的健康志愿者中采集粪便样本，这两个地区分别是格鲁利亚村（n = 195）和梅里达市（n = 181），并对粪便中耐抗生素大肠杆菌的流行情况以及分离菌株的抗生素敏感性进行分析。观察到对阿莫西林、土霉素、磺胺甲恶唑和甲氧苄啶的耐药率最高。格鲁利亚村的耐药率分别为46%、38%、44%和30%；梅里达市的耐药率分别为39%、65%、56%和36%。在梅里达市，发现土霉素的耐药率显著更高（P < 0.05）。观察到格鲁利亚村和梅里达市之间阿莫西林、氯霉素和土霉素的MIC值分布存在显著差异（P < 0.05）。在格鲁利亚村，最常见的模式是仅对阿莫西林耐药，而在梅里达市是仅对土霉素耐药。阿莫西林耐药是由于产生了TEM1β-内酰胺酶。
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