IS231A转座：保守途径与复制途径

IS231A transposition: conservative versus replicative pathway.

作者信息

Léonard C, Mahillon J

机构信息

Laboratoire de Génétique Microbienne, Université catholique de Louvain, Louvain-la-Neuve, Belgium.

出版信息

Res Microbiol. 1998 Sep;149(8):549-55. doi: 10.1016/s0923-2508(99)80002-3.

DOI:10.1016/s0923-2508(99)80002-3

PMID:9795992

Abstract

This paper describes a novel approach, based on suicide transposition, to addressing the question of whether IS231A can give rise to cointegrate molecules through replicative transposition, even at a very low frequency. Comparative analysis was carried out with IS 10, another member of the same IS4 family. The results indicate that transposition of both elements is exclusively conservative.

摘要

本文描述了一种基于自杀性转座的新方法，用于解决即使在非常低的频率下，IS231A是否能通过复制性转座产生共整合分子这一问题。我们将其与同一IS4家族的另一个成员IS10进行了比较分析。结果表明，这两种元件的转座均完全是保守性的。