Henry T R, Pennell P B
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.
Q J Nucl Med. 1998 Sep;42(3):199-210.
Functional neuroimaging with positron and single photon emitter-labeling has added considerably to the understanding of epileptic seizure activity and of the postictal and interictal cerebral dysfunctions that accompany many epilepsies. Some of these functional alterations cannot be studied in humans by any other technique, and in other instances the information is complementary to that provided by other techniques, some of which are invasive or even require tissue destruction. Available radiotracer imaging techniques have yet to be fully applied to several important epileptic syndromes (including the Lennox-Gastaut syndrome and other secondary generalized epilepsies), to physiological aspects of the natural history of temporal lobe epilepsy or any other commonly occurring epilepsy, and to the assessment of mechanisms of action and adverse effects of antiepileptic drugs and other epilepsy therapies. New radiotracers should be developed to permit study of specific excitatory amino acid receptors and other receptor sites that are known to be relevant to the development of epilepsy, to the onset of individual seizures, and to interictal dysfunctions.
利用正电子和单光子发射体标记的功能神经成像，极大地增进了我们对癫痫发作活动以及许多癫痫所伴随的发作后和发作间期脑功能障碍的理解。其中一些功能改变无法通过任何其他技术在人体中进行研究，而在其他情况下，这些信息与其他技术所提供的信息互为补充，其中一些技术具有侵入性，甚至需要破坏组织。现有的放射性示踪剂成像技术尚未完全应用于几种重要的癫痫综合征（包括Lennox-Gastaut综合征和其他继发性全身性癫痫）、颞叶癫痫或任何其他常见癫痫自然史的生理方面，以及抗癫痫药物和其他癫痫治疗的作用机制和不良反应评估。应开发新的放射性示踪剂，以便研究已知与癫痫发展、个体发作起始以及发作间期功能障碍相关的特定兴奋性氨基酸受体和其他受体位点。
