Kimura K, Sunagawa T, Yajima S, Miyake S, Yokoyama M
Department of Applied Chemistry, Faculty of Systems Engineering, Wakayama University, Japan.
Anal Chem. 1998 Oct 15;70(20):4309-13. doi: 10.1021/ac9805706.
Sol-gel-derived membranes incorporating crown ether neutral carriers by covalent bonding have been designed for durable, nontoxic neutral carrier-type ion sensors by sol-gel processing using tetraethoxysilane, diethoxydimethylsilane, and their corresponding alkoxysilylated neutral carriers. A tetraphenylborate anion was also bound chemically to the neutral carrier-type sol-gel-derived membranes for suppressing anion interference and membrane impedance. Ion-sensitive field effect transistors (ISFETs) based on the sol-gel-derived membranes modified chemically by crown ether derivatives, such as 16-crown-5 and bis(12-crown-4) derivatives, showed high performance, high sensitivity in wide cation activity ranges, short response time, and high electrode durability. Specifically, high ion selectivities of practical use in biological systems were attained in the sodium ISFETs based on the chemically modified bis(12-crown-4), which has been successfully applied to sodium assay in blood sera.
通过使用四乙氧基硅烷、二乙氧基二甲基硅烷及其相应的烷氧基硅烷基化中性载体，利用溶胶 - 凝胶工艺设计了通过共价键结合冠醚中性载体的溶胶 - 凝胶衍生膜，用于耐用、无毒的中性载体型离子传感器。还将四苯硼酸盐阴离子化学结合到中性载体型溶胶 - 凝胶衍生膜上，以抑制阴离子干扰和膜阻抗。基于用冠醚衍生物（如16 - 冠 - 5和双（12 - 冠 - 4）衍生物）化学修饰的溶胶 - 凝胶衍生膜的离子敏感场效应晶体管（ISFET）表现出高性能、在宽阳离子活性范围内的高灵敏度、短响应时间和高电极耐久性。具体而言，基于化学修饰的双（12 - 冠 - 4）的钠ISFET在生物系统中实际应用时具有高离子选择性，该传感器已成功应用于血清中的钠含量测定。
