Agewall S, Wikstrand J, Fagerberg B
Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden.
J Hypertens. 1998 Apr;16(4):537-41. doi: 10.1097/00004872-199816040-00016.
Haemostatic factors may play a part in the development of acute coronary heart disease.
To evaluate as predictors of major coronary events (fatal and non-fatal myocardial infarctions and sudden death) levels of fibrinogen, von Willebrand factor, prothrombin fragment 1+2, thrombin-antithrombin complex, plasminogen activator inhibitor activity and C-reactive protein.
We studied 131 men, aged 56-77 years, with treated hypertension and at least one additional cardiovascular risk factor (hypercholesterolaemia, diabetes mellitus or smoking). These patients were recruited from a continuing risk factor intervention study. The mean observation time was 3.0 years.
Fourteen patients died and 16 had a major coronary event during the follow-up period. After adjustments for other risk factors, levels of prothrombin fragment 1+2 and C-reactive protein were independent predictors of major coronary events. The other measured haemostatic variables were not significantly associated with major coronary events during follow-up. Fibrinogen and prothrombin fragment 1+2 levels were independent predictors for mortality.
Among treated hypertensive men, levels of prothrombin fragment 1+2 and C-reactive protein were independent predictors of major coronary events.
止血因子可能在急性冠状动脉疾病的发生发展中起作用。
评估纤维蛋白原、血管性血友病因子、凝血酶原片段1+2、凝血酶-抗凝血酶复合物、纤溶酶原激活物抑制剂活性及C反应蛋白水平作为主要冠状动脉事件（致命和非致命性心肌梗死及猝死）预测指标的价值。
我们研究了131名年龄在56至77岁之间、患有高血压且至少还有一种其他心血管危险因素（高胆固醇血症、糖尿病或吸烟）的男性。这些患者来自一项持续的危险因素干预研究。平均观察时间为3.0年。
随访期间，14名患者死亡，16名发生主要冠状动脉事件。在对其他危险因素进行校正后，凝血酶原片段1+2水平和C反应蛋白水平是主要冠状动脉事件的独立预测指标。其他检测的止血变量在随访期间与主要冠状动脉事件无显著相关性。纤维蛋白原和凝血酶原片段1+2水平是死亡率的独立预测指标。
在接受治疗的高血压男性中，凝血酶原片段1+2水平和C反应蛋白水平是主要冠状动脉事件的独立预测指标。
