产后类风湿关节炎发病的预测。
Prediction of postpartum onset of rheumatoid arthritis.
作者信息
Iijima T, Tada H, Hidaka Y, Yagoro A, Mitsuda N, Kanzaki T, Murata Y, Amino N
机构信息
Department of Laboratory Medicine, Osaka University Medical School, Japan.
出版信息
Ann Rheum Dis. 1998 Aug;57(8):460-3. doi: 10.1136/ard.57.8.460.
OBJECTIVE
To investigate the prediction of the postpartum onset of rheumatoid arthritis (RA).
METHODS
Two thousand five hundred and forty seven healthy pregnant subjects were examined prospectively and the relation between serum rheumatoid factors (RF) and postpartum onset of RA was observed. Rheumatoid factors were measured in early pregnancy by the antihuman IgG latex agglutination test (Latex test) and antirabbit IgG haemagglutination test (RAHA test).
RESULTS
Latex test and RAHA test were positive in 26 (1.0%) and 64 (2.5%) pregnant subjects, respectively. Four hundred and ten subjects of 2547 pregnant women could be followed up for one year after delivery. None of 401 subjects without RF, or with only one RF on either Latex test or RAHA test, developed RA after delivery. Two (22.2%) of nine subjects with both RFs developed RA at one and three months postpartum, respectively. Transient arthralgia was found within 12 months postpartum in three of nine (33.3%) subjects with both RFs and this prevalence was significantly higher than that in RF negative subjects (8.1%).
CONCLUSION
Postpartum onset of RA was found in at least 2 of 2547 healthy subjects (0.08%) and onset was predicted by positive test for rheumatoid factors.
目的
研究类风湿关节炎（RA）产后发病的预测情况。
方法
对2547名健康孕妇进行前瞻性检查，观察血清类风湿因子（RF）与RA产后发病之间的关系。在妊娠早期通过抗人IgG乳胶凝集试验（乳胶试验）和抗兔IgG血凝试验（RAHA试验）检测类风湿因子。
结果
乳胶试验和RAHA试验在孕妇中的阳性率分别为26例（1.0%）和64例（2.5%）。2547名孕妇中有410名在产后可随访1年。401名无RF或仅在乳胶试验或RAHA试验中一项RF阳性的受试者产后均未发生RA。9名两项RF均阳性的受试者中有2名（22.2%）分别在产后1个月和3个月发生RA。9名两项RF均阳性的受试者中有3名（33.3%）在产后12个月内出现短暂性关节痛，这一患病率显著高于RF阴性受试者（8.1%）。
结论
在2547名健康受试者中至少有2名（0.08%）发生了RA产后发病，类风湿因子检测阳性可预测发病。
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