Notelovitz M
Women's Medical and Diagnostic Center, Gainesville, Florida, USA.
Gynecol Endocrinol. 1998 Aug;12(4):248-58.
In the future, hormone replacement therapy (HRT) is likely to become of increasing importance, not only to control short-term climacteric symptoms, but also to protect postmenopausal women from the increasing risk of cardiovascular disease, osteoporosis and other conditions that accompany ovarian failure. This paper reviews the principles and practice associated with HRT, focusing on clinical experience with a new 7-day estrogen matrix patch (Climara). Results from two 11-week placebo-controlled studies, which compared the 7-day patch at two dose levels with 0.625-mg/day oral conjugated equine estrogen, found that both the 0.5- and 0.1-mg estradiol/day patches had a positive effect on climacteric symptoms. Tolerance was good and similar for both patches. Separate studies of skin irritation and adhesion revealed that the 7-day patch was well tolerated and that, although irritation was similar to that associated with Estraderm, adhesion was superior with the 7-day patch. Data on absorption of estradiol from different skin sites indicate that absorption is higher and more consistent from the buttock than from the abdomen, suggesting that choice of application site may require further investigation.
未来，激素替代疗法（HRT）可能会变得越来越重要，这不仅是为了控制短期的更年期症状，也是为了保护绝经后女性免受伴随卵巢功能衰竭而来的心血管疾病、骨质疏松症和其他疾病风险增加的影响。本文综述了与HRT相关的原理和实践，重点介绍了一种新型7天雌激素基质贴片（克龄蒙）的临床经验。两项为期11周的安慰剂对照研究结果，将两种剂量水平的7天贴片与0.625毫克/天的口服结合马雌激素进行比较，发现0.5毫克/天和0.1毫克/天的雌二醇贴片对更年期症状均有积极作用。两种贴片的耐受性都很好且相似。关于皮肤刺激和粘贴性的单独研究表明，7天贴片耐受性良好，虽然刺激情况与雌二醇贴片相似，但7天贴片的粘贴性更优。不同皮肤部位雌二醇吸收的数据表明，臀部的吸收高于腹部且更一致，这表明应用部位的选择可能需要进一步研究。
