Frykberg R G
Division of Podiatry, Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA, USA.
J Foot Ankle Surg. 1998 Sep-Oct;37(5):440-6. doi: 10.1016/s1067-2516(98)80055-0.
Foot ulcerations and their sequelae remain a major source of morbidity for patients with diabetes mellitus. Often leading to infection, osteomyelitis, or gangrene, these lesions have consistently been ascertained as significant risk factors for subsequent lower extremity amputation. Hence education, appropriate foot care, and early intervention have assumed important roles in programs focused on amputation prevention. Multidisciplinary cooperation has been demonstrated as the most successful approach to the management and prevention of foot lesions in patients with diabetes. This article reviews the epidemiology, current understanding of the underlying pathophysiology, and treatment rationale for diabetic foot ulcerations. Such knowledge is essential in the overall management of these complicated patients and, when incorporated into daily practice, can significantly reduce the incidence and morbidity of foot disease in diabetes.
足部溃疡及其后遗症仍然是糖尿病患者发病的主要原因。这些病变常常导致感染、骨髓炎或坏疽，一直被确定为随后下肢截肢的重要危险因素。因此，教育、适当的足部护理和早期干预在以预防截肢为重点的项目中发挥着重要作用。多学科合作已被证明是管理和预防糖尿病患者足部病变的最成功方法。本文综述了糖尿病足溃疡的流行病学、对潜在病理生理学的当前认识以及治疗原理。这些知识对于这些复杂患者的整体管理至关重要，并且当纳入日常实践时，可以显著降低糖尿病足部疾病的发病率。
