Jordan W D, Sampson L K, Iyer S, Anderson P G, Lyle K, Brown R J, Luo J, Roubin G S
Department of Surgery, University of Alabama at Birmingham School of Medicine, 35294, USA.
Am Surg. 1998 Nov;64(11):1070-3.
Abdominal aortic aneurysms (AAAs) are the 13th leading cause of death in the United States. Endovascular stent grafts are currently being investigated in clinical trials as an alternative method for treatment of AAA. Twelve pigs underwent creation of AAA using the abdominus rectus fascia. Postoperatively, all 12 animals underwent angiography, which demonstrated turbulent flow within the created aneurysms. Four of the animals were not stented and served as controls. Eight animals underwent subsequent percutaneous placement of a covered endovascular stent via a right femoral sheath, and the stents were deployed between the renal arteries and the aortic bifurcation. The animals were maintained for 120 days before sacrifice and necropsy. Unstented animals (4) died within 6 days, 3 from rupture. Eight animals underwent endovascular stenting: 5 survived without complications, 3 deaths within 2 days were related to technical complications. The 5 surviving animals were sacrificed at 120 days, and necropsy was conducted with in situ dissections of the aorta and intact stent: 3 experimental animals had correct anatomic positioning of the stent, and 2 had inexact stent placement but survived 120 days with AAA thrombosis. Treatment of AAA in this swine model has been demonstrated via placement of a percutaneous covered stent.
腹主动脉瘤（AAA）是美国第13大死因。目前，血管内支架移植物正在临床试验中作为治疗AAA的替代方法进行研究。12头猪通过腹直肌筋膜制作了AAA。术后，所有12只动物均接受了血管造影，结果显示所形成的动脉瘤内血流紊乱。其中4只动物未植入支架作为对照。8只动物随后通过右股鞘经皮放置带膜血管内支架，支架部署在肾动脉和主动脉分叉之间。在处死和尸检前将动物饲养120天。未植入支架的动物（4只）在6天内死亡，3只因破裂死亡。8只动物接受了血管内支架植入术：5只存活且无并发症，3只在2天内死亡与技术并发症有关。5只存活的动物在120天时被处死，并对主动脉和完整支架进行原位解剖尸检：3只实验动物的支架解剖位置正确，2只支架放置不准确，但在AAA血栓形成的情况下存活了120天。通过经皮放置带膜支架已证明在该猪模型中可治疗AAA。
