Haberal M, Karakayali H, Moray G, Demirag A, Yildirim S, Bilgin N
Başkent University School of Medicine, Department of General Surgery, Ankara, Turkey.
Clin Nephrol. 1998 Oct;50(4):232-5.
This study evaluated 102 randomly selected living-related kidney donors who were operated between November 1975 and December 1996 after a mean follow-up period of 10.2 years (range 8 months to 22 years). The donor male:female ratio was 45:57, and mean age was 41.0 years (range 21 to 65 years). The average preoperative and last follow-up blood creatinine levels were 73.37 micromol/l (range 44.2-106.8 micromol/l) and 78.67 micromol/l (range 8.84-318.2 micromol/l), respectively (p:NS), and the corresponding average creatinine clearance values were 108.4 ml/min (range 100-130 ml/min) and 96.8 ml/min (range 27 to 125 ml/min) (p: NS). Four donors had 24-hour urine protein excretion above 0.1 gram (2 G, 0.7 G, 0.2 G, and 0.14 G, specifically). The donors' mean systolic blood pressures before, and after the operation on the last follow-up were 131.7 +/- 21.2 mmHg and 139.6 +/- 20.9 mmHg, respectively (p:NS). Nine donors (8.8%) developed hypertension which required anti-hypertensive treatment. The mean age of the hypertensive group was 48.0 years (range 30 to 65 years), whereas that for the nonhypertensive group was 39.4 years (range 18 to 76 years) (p <0.02). Only one donor (0.9%), a 41 year-old female, was diagnosed with chronic renal disease related to pyelonephritis. These results support the utilization of living donors for kidney transplantation, an option which helps broaden a limited donor pool.
本研究评估了1975年11月至1996年12月间随机选取的102名活体亲属肾供体，平均随访期为10.2年（范围8个月至22年）。供体男女比例为45:57，平均年龄为41.0岁（范围21至65岁）。术前和末次随访时的平均血肌酐水平分别为73.37微摩尔/升（范围44.2 - 106.8微摩尔/升）和78.67微摩尔/升（范围8.84 - 318.2微摩尔/升）（p：无统计学意义），相应的平均肌酐清除率分别为108.4毫升/分钟（范围100 - 130毫升/分钟）和96.8毫升/分钟（范围27至125毫升/分钟）（p：无统计学意义）。4名供体24小时尿蛋白排泄量超过0.1克（具体为2克、0.7克、0.2克和0.14克）。供体在术前和末次随访手术时的平均收缩压分别为131.7±21.2毫米汞柱和139.6±20.9毫米汞柱（p：无统计学意义）。9名供体（8.8%）发生高血压，需要进行抗高血压治疗。高血压组的平均年龄为48.0岁（范围30至65岁），而非高血压组为39.4岁（范围18至76岁）（p<0.02）。仅1名供体（0.9%），一名41岁女性，被诊断为与肾盂肾炎相关的慢性肾病。这些结果支持将活体供体用于肾移植，这一选择有助于扩大有限的供体库。
