Troisi R, Weiss H A, Hoover R N, Potischman N, Swanson C A, Brogan D R, Coates R J, Gammon M D, Malone K E, Daling J R, Brinton L A
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-7374, USA.
Epidemiology. 1998 Nov;9(6):641-7.
In a population-based case-control study of parous women less than 45 years of age, we evaluated the relations of various pregnancy characteristics to maternal breast cancer risk. Cases (N = 1,239) diagnosed with in situ or invasive breast cancer from 1990 to 1992 in Atlanta, GA, Seattle/Puget Sound, WA, and five counties in central New Jersey, and population controls (N = 1,166) identified by random-digit dialing, were interviewed regarding the details of their pregnancies. We used logistic regression to estimate relative risks (RR) and 95% confidence intervals (CI) and to adjust for breast cancer risk factors. Women who reported nausea or vomiting in their first pregnancy had a slightly lower risk of breast cancer (RR = 0.87; 95% CI = 0.72-1.0). We found no strong or consistent associations for maternal risk related to gestational length, pregnancy weight gain, gestational diabetes, pregnancy hypertension, or gender of the offspring, although we found some evidence for reductions in risk for toxemia (RR = 0.81; 95% CI = 0.61-1.1) and specific sex (RR for female twins vs singletons = 0.48; 95% CI = 0.20-1.3) and timing characteristics of twinning. Overall, these data provide little support for the hypothesis that pregnancy hormone levels are associated with subsequent maternal risk of breast cancer in young women.
在一项针对年龄小于45岁的经产妇的基于人群的病例对照研究中，我们评估了各种妊娠特征与母亲患乳腺癌风险之间的关系。1990年至1992年期间在佐治亚州亚特兰大、华盛顿州西雅图/普吉特海湾以及新泽西州中部五个县诊断为原位或浸润性乳腺癌的病例（N = 1239），以及通过随机数字拨号确定的人群对照（N = 1166），就其妊娠细节接受了访谈。我们使用逻辑回归来估计相对风险（RR）和95%置信区间（CI），并对乳腺癌风险因素进行调整。首次怀孕时报告有恶心或呕吐的女性患乳腺癌的风险略低（RR = 0.87；95% CI = 0.72 - 1.0）。尽管我们发现了一些证据表明子痫前期风险降低（RR = 0.81；95% CI = 0.61 - 1.1）、特定性别（双胞胎女性与单胎相比的RR = 0.48；95% CI = 0.20 - 1.3）以及双胞胎的时间特征，但我们未发现与妊娠时长、孕期体重增加、妊娠糖尿病、妊娠高血压或后代性别相关的母亲风险有强烈或一致的关联。总体而言，这些数据几乎不支持妊娠激素水平与年轻女性随后患乳腺癌的母亲风险相关这一假设。
