Olson S H, Zauber A G, Tang J, Harlap S
Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Epidemiology. 1998 Nov;9(6):669-71.
We investigated whether survival was related to recent childbirth or parity in a cohort of 540 women diagnosed with breast cancer before the age of 45 years who were followed for up to 14 years. Women who had given birth within 2 years before their diagnosis of breast cancer were at increased risk of dying, compared with nulliparous women, with an adjusted relative risk of 3.1 (95% confidence interval = 1.8-5.4). There was a moderate association of parity with mortality, with an adjusted relative risk of 1.8 (95% confidence interval = 1.2-2.9) for women with three or more births, compared with nulliparous women.
我们对540名45岁之前被诊断为乳腺癌的女性进行了长达14年的随访，以调查生存率是否与近期分娩或生育胎次有关。与未生育女性相比，在诊断为乳腺癌前2年内分娩的女性死亡风险增加，调整后的相对风险为3.1（95%置信区间=1.8-5.4）。生育胎次与死亡率存在中度关联，与未生育女性相比，生育三次或更多次的女性调整后的相对风险为1.8（95%置信区间=1.2-2.9）。
