使用加味归脾汤治疗的特发性血小板减少性紫癜患者的人类白细胞抗原（HLA）和人类血小板抗原（HPA）分型

HLA and HPA typing in idiopathic thrombocytopenic purpura patients treated with Kami-kihi-to.

作者信息

Matsuzaki T, Nomura S, Yamaoka M, Ozaki Y, Yoshimura C, Xie G L, Katsura K, Kagawa H, Ishida T, Fukuhara S

机构信息

Department of Blood Transfusion, Kansai Medical University, Osaka, Japan.

出版信息

Am J Chin Med. 1998;26(2):191-8. doi: 10.1142/S0192415X98000245.

DOI:10.1142/S0192415X98000245

PMID:9799971

Abstract

We performed human leukocyte antigen (HLA) and human platelet antigen (HPA) in patients with Kami-kihi-to-responsive idiopathic thrombocytopenic purpura. The HLA-A2, A61 and Cw1 were significantly increased in responders compared with nonresponders, as were HLA DRB1 *0901, DRB1 *1502, and DPB1 *0501. In contrast, HLA DPB1 *0201 and DPB1 *0901 were significantly decreased in responders. The a/b genotype of HPA-2 and a/a genotype of HPA-3 were markedly increased in nonresponders, and anti-GPIb antibody was also increased. These results suggest that HLA, HPA, and anti-GP antibody studies may predict the response of idiopathic thrombocytopenic purpura to Kami-kihi-to.

摘要

我们对 kami-kihi-to 反应性特发性血小板减少性紫癜患者进行了人类白细胞抗原（HLA）和人类血小板抗原（HPA）检测。与无反应者相比，反应者中 HLA-A2、A61 和 Cw1 显著增加，HLA DRB1 *0901、DRB1 *1502 和 DPB1 *0501 也是如此。相比之下，反应者中 HLA DPB1 *0201 和 DPB1 *0901 显著降低。无反应者中 HPA-2 的 a/b 基因型和 HPA-3 的 a/a 基因型明显增加，抗 GPIb 抗体也增加。这些结果表明，HLA、HPA 和抗 GP 抗体研究可能预测特发性血小板减少性紫癜对 kami-kihi-to 的反应。