Henderson B E, Louie E, SooHoo Jing J, Buell P, Gardner M B
N Engl J Med. 1976 Nov 11;295(20):1101-6. doi: 10.1056/NEJM197611112952003.
We performed a case-control study of nasopharyngeal squamous-cell carcinoma to identify risk factors associated with the disease. Interviews with 156 patients and 267 controls revealed that increased risk was significantly associated with a prior history of ear, nose or throat disease (relative risk = 1.8, P = 0.006) and occupational exposure to fumes (relative risk = 2.0, P = 0.006), smoke (relative risk = 3.0, P = 0.008) and chemicals (relative risk = 2.4, P = 0.006). Among Chinese, other Asians and Mexican-Americans, increased risk was also associated with foreign birthplace (relative risk = 2.1, P = 0.04), probably reflecting childhood exposure to carcinogens in inhaled smoke. In Chinese patients the risk associated with foreign birthplace and occupational exposure increased among those with HLA-A2 and less than two antigens at the B locus, suggesting a genetic variation in susceptibility.
我们开展了一项关于鼻咽鳞状细胞癌的病例对照研究，以确定与该疾病相关的风险因素。对156例患者和267名对照者进行的访谈显示，风险增加与既往耳、鼻或喉疾病史（相对风险=1.8，P=0.006）以及职业性接触烟雾（相对风险=2.0，P=0.006）、烟尘（相对风险=3.0，P=0.008）和化学物质（相对风险=2.4，P=0.006）显著相关。在中国人群、其他亚洲人群和墨西哥裔美国人中，风险增加还与出生地为外国有关（相对风险=2.1，P=0.04），这可能反映了儿童时期暴露于吸入烟雾中的致癌物。在中国患者中，出生地为外国和职业性接触相关的风险在那些具有HLA - A2且B位点抗原少于两种的患者中增加，这表明易感性存在基因变异。
