Kranzler H R, Skipsey K, Modesto-Lowe V
Department of Psychiatry, University of Connecticut School of Medicine, Farmington 06030-2103, USA.
Drug Alcohol Depend. 1998 Oct 1;52(2):109-13. doi: 10.1016/s0376-8716(98)00081-7.
Pelchat and Danowski [Physiol. Behav. 1992;51:1261-1266] reported an association between the ability to taste 6-n-propylthiouracil (PROP) and a parental history of alcoholism. Kranzler et al. [Alcohol Clin. Exp. Res. 1996a;20:1496-1500] previously failed to replicate these findings in a sample of subjects with only a paternal history of alcohol dependence. The present study was conducted to examine this putative association in a sample of subjects that is heterogeneous with respect to parental alcoholism history. Among the 90 alcohol-dependent subjects studied, the proportion of PROP nontasters was comparable to that observed among nonalcoholics. Analysis revealed no association of parental history with PROP taster status, even after controlling for potential confounding variables. We conclude that no reliable association exists between taste sensitivity to PROP and either a diagnosis of alcohol dependence or a parental history of alcohol dependence.
佩尔查特和达诺夫斯基[《生理与行为》，1992年；51:1261 - 1266]报告了对6 - 正丙基硫氧嘧啶（PROP）的味觉能力与酗酒家族史之间的关联。克兰兹勒等人[《酒精临床与实验研究》，1996年a卷；20:1496 - 1500]之前在仅有父亲酗酒史的受试者样本中未能重复这些发现。本研究旨在对一组父母酗酒史各异的受试者样本进行此项假定关联的检验。在研究的90名酒精依赖受试者中，PROP味盲者的比例与非酒精依赖者中观察到的比例相当。分析显示，即使在控制了潜在的混杂变量之后，父母酗酒史与PROP味觉状态之间也没有关联。我们得出结论，对PROP的味觉敏感性与酒精依赖诊断或父母酗酒史之间不存在可靠的关联。
