Sirén M K, Koponen A, Kekomäki R
Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Transfus Med. 1998 Sep;8(3):221-4. doi: 10.1046/j.1365-3148.1998.00152.x.
We describe an alloimmunized female patient who developed serious adverse reactions when receiving HPA-incompatible platelet transfusions. She had received 13 transfusions with random platelets before the first allergic reactions. Antibodies against both the human leucocyte antigens (HLA) and several human platelet antigens (HPA) were detected at the time of transfusions. When the patient received HLA- and HPA-compatible platelets, no reactions followed the transfusions and platelet count increments were good. When she was transfused with platelets from donors with one foreign HLA antigen, her reactions were fever, chills and headache and the response to platelet transfusions was poor. When the platelets were HLA compatible but HPA incompatible, the reactions were repeatedly rapid pulse, shortness of breath, tightness of chest and wheezing interpretable as anaphylactoid reactions. Platelet count increments were satisfactory. When rare side-effects occur after transfusion, detailed immunohaematological studies are indicated.
我们描述了一名同种免疫的女性患者，她在接受与人类血小板抗原（HPA）不匹配的血小板输注时出现了严重不良反应。在首次出现过敏反应之前，她已接受了13次随机血小板输注。输血时检测到针对人类白细胞抗原（HLA）和几种人类血小板抗原（HPA）的抗体。当患者接受与HLA和HPA匹配的血小板时，输血后未出现反应，血小板计数增加良好。当她输注来自具有一种外来HLA抗原供体的血小板时，她的反应为发热、寒战和头痛，对血小板输注的反应较差。当血小板HLA匹配但HPA不匹配时，反应反复为脉搏快速、呼吸急促、胸部发紧和喘息，可解释为类过敏反应。血小板计数增加令人满意。当输血后出现罕见的副作用时，需要进行详细的免疫血液学研究。
