Madhu B, Hjärtstam J, Soussi B
Bioenergetics Group, Wallenberg Laboratory and Lundberg Laboratory for Bioanalysis, University of Göteborg, S-413 45, Göteborg, Sweden.
J Control Release. 1998 Dec 4;56(1-3):95-104. doi: 10.1016/s0168-3659(98)00069-8.
Nuclear Magnetic Resonance (NMR) microscopy was used to study the dynamics and diffusion of the internal water flow in erodible Hydroxypropylmethylcellulose (HPMC) and Polyvinylalcohol (PVA) polymers of pharmaceutical interest. Polymers in the form of tablets were hydrated at 37 degreesC continuously and monitored at regular intervals with a 500 MHz NMR microscope. The diffusion and spin-spin relaxation time (T2)-weighted images revealed that the gel layer was strongly attached to the core of the tablet in both HPMC and PVA polymers. Spatial distribution of self diffusion coefficients (SDCs) and T2 of the hydrating polymers were calculated from NMR microscopic images.
核磁共振（NMR）显微镜被用于研究具有药学意义的可侵蚀羟丙基甲基纤维素（HPMC）和聚乙烯醇（PVA）聚合物内部水流的动力学和扩散情况。片剂形式的聚合物在37摄氏度下持续水化，并使用500兆赫的NMR显微镜定期进行监测。扩散和自旋-自旋弛豫时间（T2）加权图像显示，在HPMC和PVA聚合物中，凝胶层都与片剂核心紧密相连。根据NMR显微镜图像计算了水化聚合物的自扩散系数（SDCs）和T2的空间分布。
