Raimo E B, Schuckit M A
University of California, San Diego, USA.
Addict Behav. 1998 Nov-Dec;23(6):933-46. doi: 10.1016/s0306-4603(98)00068-9.
This article explores the complex relationships between alcohol dependence and mood disorders. Although many alcoholics present with substance-induced depressions, once appropriate methodological controls are used, there does not appear to be a significant relationship between independent unipolar depression and alcohol dependence. However, the data support a small, but significant, relationship between bipolar manic-depressive disease and alcoholism. The literature does not support the relevance of self-medication as a course of alcoholism, unless one includes the use of alcohol to alleviate alcohol-induced psychological and neurochemical perturbations. The clinical importance of distinguishing between substance-induced and independent mood disorders is reviewed.
本文探讨了酒精依赖与情绪障碍之间的复杂关系。尽管许多酗酒者存在物质所致的抑郁，但一旦采用适当的方法学控制，单相抑郁与酒精依赖之间似乎不存在显著关系。然而，数据支持双相躁狂抑郁症与酒精中毒之间存在小但显著的关系。除非将使用酒精来缓解酒精所致的心理和神经化学紊乱包括在内，否则文献并不支持自我用药作为酗酒的一个过程。本文还综述了区分物质所致和独立情绪障碍的临床重要性。
