Maes M, Goossens F, Lin A, De Meester I, Van Gastel A, Scharpé S
Clinical Research Center for Mental Health (CRC-MH), Antwerp, Belgium.
Psychoneuroendocrinology. 1998 Jul;23(5):485-95. doi: 10.1016/s0306-4530(98)00020-1.
There is now some evidence that psychiatric disorders, such as major depression, schizophrenia and post-traumatic stress disorder are associated with significant alterations in the serum activity of peptidases, such as prolyl endopeptidase (PEP) and dipeptidyl peptidase IV (DPP IV). The aims of the present study were to examine the effects of psychological stress on serum PEP and DPP IV activity in humans. Thirty-eight university students had repeated measurements of serum PEP and DPP IV activity a few weeks before and after (baseline conditions) as well as the day before a difficult academic examination (stress condition). Subjects were divided into anxiety responders and nonresponders to stress according to their stress-induced increase in the Spielberger State Anxiety Inventory. Serum PEP activity was somewhat lowered by stress in female, but not male, students. Serum PEP activity was significantly higher in the two baseline conditions and during the stress condition in anxiety responders than in anxiety nonresponders. There were no significant effects of stress on serum DPP IV activity and no significant differences between anxiety responders and nonresponders. Serum PEP and DPP IV activity were significantly higher in men than in women. The results suggest that increased baseline serum PEP activity is related to stress-induced anxiety.
目前有一些证据表明，诸如重度抑郁症、精神分裂症和创伤后应激障碍等精神疾病与肽酶（如脯氨酰内肽酶（PEP）和二肽基肽酶IV（DPP IV））的血清活性显著改变有关。本研究的目的是检验心理应激对人类血清PEP和DPP IV活性的影响。38名大学生在（基线条件下）困难的学术考试前几天以及考试前一天（应激条件下）对血清PEP和DPP IV活性进行了重复测量。根据他们在斯皮尔伯格状态焦虑量表中应激诱导的增加情况，将受试者分为应激焦虑反应者和非反应者。应激使女学生而非男学生的血清PEP活性有所降低。在两个基线条件下以及应激条件下，焦虑反应者的血清PEP活性显著高于焦虑非反应者。应激对血清DPP IV活性没有显著影响，焦虑反应者和非反应者之间也没有显著差异。男性的血清PEP和DPP IV活性显著高于女性。结果表明，基线血清PEP活性增加与应激诱导的焦虑有关。
