Nakamura H, Seto T, Hatta K, Matsuzaki I, Nagase H, Yoshida M, Ogino K
Department of Public Health, Kanazawa University School of Medicine, Japan.
Psychoneuroendocrinology. 1998 Aug;23(6):651-9. doi: 10.1016/s0306-4530(98)00037-7.
To examine responses of natural killer cell activity (NKCA) to interleukin-1 beta (IL-1 beta) during pregnancy, we determined splenic NKCA as well as blood and brain indicators in virgin and pregnant rats (14 or 21 days gestation) with intracerebroventricular (i.c.v.) administration of IL-1 beta. NKCA was reduced and blood beta-endorphin (beta EP) was increased with the progress of pregnancy. I.c.v. administration of IL-1 beta reduced NKCA and corticotropin-releasing hormone (CRH) in the median eminence (ME), and increased beta EP in virgin rats, but did not change any parameters in pregnant rats with 21 days gestation. These data suggest that the immunosuppressive effect of central administration of IL-1 beta is blocked by pregnancy. CRH in the ME and opioid system seem to be involved in the inhibitory effect of pregnancy on IL-1 beta-induced immunosuppression.
为研究孕期自然杀伤细胞活性（NKCA）对白介素-1β（IL-1β）的反应，我们通过脑室内（i.c.v.）注射IL-1β，测定了未孕和孕鼠（妊娠14或21天）的脾脏NKCA以及血液和脑内指标。随着妊娠进展，NKCA降低，血液β-内啡肽（βEP）增加。脑室内注射IL-1β可降低未孕大鼠的NKCA和正中隆起（ME）中的促肾上腺皮质激素释放激素（CRH），并增加βEP，但对妊娠21天的孕鼠的任何参数均无影响。这些数据表明，孕期可阻断中枢给予IL-1β的免疫抑制作用。ME中的CRH和阿片系统似乎参与了孕期对IL-1β诱导的免疫抑制的抑制作用。
