Williams F, Curran M D, Middleton D
Northern Ireland Regional Histocompatibility and Immunogenetics Laboratory, City Hospital, Belfast.
Tissue Antigens. 1998 Sep;52(3):208-12. doi: 10.1111/j.1399-0039.1998.tb03034.x.
A number of cases have been identified (seven unrelated individuals from the Northern Ireland bone marrow donor registry and two family groups) where an HLA-A*24 allele fails to express the normal HLA-A24 antigen. Family information has revealed common haplotypes with respect to each non-expressed allele indicating that the occurrence of these mutations has been a recent event. Two methods for the clinical typing of these alleles have been evaluated--PCR-SSOP and PCR-SSCP analysis.
已发现多例（北爱尔兰骨髓捐献者登记处的7名无亲缘关系个体以及两个家族群体）HLA-A*24等位基因无法表达正常HLA-A24抗原的情况。家族信息显示，每个未表达等位基因都有共同的单倍型，这表明这些突变是近期发生的。已评估了两种对这些等位基因进行临床分型的方法——PCR-SSOP和PCR-SSCP分析。
