Marta-Moreno E, Alarcia R, Bestúe M, López-Gastón J, Marta-Moreno J, Guelbenzu S
Servicio de Neurología, Hospital Miguel Servet, Zaragoza, España.
Rev Neurol. 1998 Oct;27(158):589-91.
The intracranial hypotension syndrome is characterized by a cerebrospinal fluid (CSF) pressure of less than 60 mmH2O and presents as postural hypotension which is often accompanied by nausea, vomiting, cervicalgia and some degree of neck rigidity. It is considered to be spontaneous when there is no known precipitating factor. It is believed that there is a CSF leak across the subarachnoid space, although it is not always possible to detect this. In recent years several authors have described different pathological findings on magnetic resonance (MR) studies.
We present the radiological studies of a patient with clinical evidence of headache which was worse on standing and improved when lying down. The outflow pressure of CSF was 6 mmH2O when lying down. On isotopic cisternography using Tc DTPA-99m there was no detectable CSF leak. On cerebral MR there was diffuse pachymeningeal thickening with increased signals in T1 sequences. This was more pronounced in T2 with lineal dural uptake of contrast at infra and supratentorial levels. The brain stem meninges were intact. In parallel with a favorable clinical course, following clinical resolution the radiological images were seen to have returned to normal.
Radiological findings, together with a compatible clinical condition, help to establish the diagnosis of spontaneous intracranial hypotension and avoids the use of unnecessary clinical investigations.
颅内低压综合征的特征是脑脊液(CSF)压力低于60 mmH₂O,表现为体位性低血压,常伴有恶心、呕吐、颈部疼痛和一定程度的颈部僵硬。当没有已知的诱发因素时,被认为是自发性的。尽管并非总能检测到,但人们认为存在脑脊液通过蛛网膜下腔漏出的情况。近年来,几位作者描述了磁共振(MR)研究中的不同病理发现。
我们展示了一名有临床证据表明头痛在站立时加重、躺下时缓解的患者的影像学研究。躺下时脑脊液的流出压力为6 mmH₂O。在使用锝-99m二乙三胺五醋酸(Tc DTPA-99m)的同位素脑池造影中,未检测到脑脊液漏。在脑部磁共振成像中,可见硬脑膜弥漫性增厚,T1序列信号增强。在T2序列中更明显,幕下和幕上层面有线性硬脑膜对比剂摄取。脑干脑膜完整。随着临床过程好转,临床症状缓解后,影像学图像恢复正常。
影像学表现,结合相符的临床情况,有助于确立自发性颅内低压的诊断,并避免进行不必要的临床检查。