Johnson T
Medical Research Council Biostatistics Unit, University Forvie Site, Cambridge, UK.
Stat Methods Med Res. 1998 Sep;7(3):209-34. doi: 10.1177/096228029800700302.
There have been many hundreds of studies which have examined the efficacy of different forms of treatment of psychiatric disorders over the past 40 years. This paper presents some background to these studies for statisticians, illustrating and discussing some of the difficult problems which arise in this specialty of medicine. It also demonstrates a major requirement for statisticians to influence both the design and presentation of clinical trials and provides some suggestions about how this may be done.
在过去40年里，已有数百项研究对精神疾病不同治疗形式的疗效进行了考察。本文为统计学家介绍这些研究的一些背景知识，阐述并讨论医学这一专业领域中出现的一些难题。本文还表明了统计学家对影响临床试验设计和结果呈现的一项主要要求，并就如何做到这一点提供了一些建议。
