Cobos Barroso N, Reverté Bover C, Gartner S, Liñán Cortés S, Quintó Domech L
Unitat de Pneumologia Pediàtrica i Fibrosi Quística, Hospital Universitario Materno-infantil Vall d'Hebron, Barcelona.
An Esp Pediatr. 1998 Sep;49(3):241-7.
Our aim was to study the concentration of nitric oxide in the exhaled (ENO) and nasal (NNO) air of normal children and asthmatic children who are clinically and functionally stable.
Using a nitric oxide chemiluminescence analyze and a register for CO2, pressure and flow, we studied 73 schoolchildren (6-17 years of age). This included 37 controls and 36 asthmatic children, 21 with mild asthma without antiinflammatory treatment and 15 treated with inhaled corticosteroids. We used the technique of slow exhalation against resistance for (ENO) determination and aspiration with stable flow in nasal cavity while holding the breath for (NNO) determination.
The mean ENO was 3.1 ppb (1-6) in the control group, 8.3 ppb (1.7-29.3) in the mild asthma group and 7.7 ppb (2-18.3) in the asthmatics treated with corticosteroids. There were significant differences (p = 0.0001) between the controls and both asthmatic groups. The mean NNO in the controls was 898 ppb and differences between this group and the asthmatic children were found. The ENO and NNO did not change in relation to age or sex. We did not find any relationship between ENO and lung function. There is a significant correlation between ENO and NNO in both asthmatic groups, but not in the control group.
The ENO was higher in asthmatics than in control children. The slow exhalation against resistance technique prevents the contamination of exhaled air with nasal air and this technique can be applied to children over 6 years of age. The NNO was similar in the asthmatic groups and the control group.
我们的目的是研究临床和功能稳定的正常儿童和哮喘儿童呼出气体（ENO）和鼻腔气体（NNO）中一氧化氮的浓度。
我们使用一氧化氮化学发光分析仪以及二氧化碳、压力和流量记录仪，对73名学童（6 - 17岁）进行了研究。其中包括37名对照儿童和36名哮喘儿童，21名轻度哮喘儿童未接受抗炎治疗，15名接受吸入性糖皮质激素治疗。我们采用对抗阻力缓慢呼气技术测定（ENO），并在鼻腔内以稳定气流吸气同时屏气测定（NNO）。
对照组的平均ENO为3.1 ppb（1 - 6），轻度哮喘组为8.3 ppb（1.7 - 29.3），接受糖皮质激素治疗的哮喘组为7.7 ppb（2 - 18.3）。对照组与两个哮喘组之间存在显著差异（p = 0.0001）。对照组的平均NNO为898 ppb，该组与哮喘儿童之间存在差异。ENO和NNO与年龄或性别无关。我们未发现ENO与肺功能之间存在任何关系。两个哮喘组中ENO和NNO之间存在显著相关性，但对照组中不存在。
哮喘儿童的ENO高于对照儿童。对抗阻力缓慢呼气技术可防止呼出气体被鼻腔气体污染，该技术可应用于6岁以上儿童。哮喘组和对照组的NNO相似。
