Mizutani S
Department of Virology, National Children's Medical Research Center, Tokyo, Japan.
Int J Hematol. 1998 Aug;68(2):131-43. doi: 10.1016/s0925-5710(98)00036-x.
Progress in the study of the biological characteristics of cancer and genetic factors, such as genomic stability, DNA repair, cell-cycle control, and genes encoding enzymes involved in carcinogen metabolism and detoxication, is changing our insight into how heredity contributes to the risk of childhood leukemia. Although familial leukemia is very rare, the role of inherited genes in the etiology of acute leukemia needs to be reevaluated. Our understanding of genetic factors predisposing individuals to certain types of leukemia might also implicate environmental factors as an additional risk factor in the development of leukemia. Recent progress in the study of the hereditary and environmental factors of childhood leukemia is reviewed and discussed here.
癌症生物学特性以及基因因素（如基因组稳定性、DNA修复、细胞周期调控，以及参与致癌物代谢和解毒的酶编码基因）研究方面的进展，正在改变我们对于遗传因素如何影响儿童白血病发病风险的认识。尽管家族性白血病非常罕见，但仍需重新评估遗传基因在急性白血病病因学中的作用。我们对于使个体易患特定类型白血病的遗传因素的理解，也可能表明环境因素是白血病发生发展中的另一个风险因素。本文对儿童白血病遗传和环境因素研究的最新进展进行了综述和讨论。
