Datta C K, Weinstein J D, Bland J E, Brager P M, Stewart M A
United Hospital Center, Clarksburg, USA.
W V Med J. 1998 Sep-Oct;94(5):276-8.
This article presents a rare case of metastatic glioblastoma multiforme (GM) to the cervical lymph node. In spite of very aggressive tumor behavior, extracranial metastasis from intra-cerebral GM is rare. Only a few cases are reported in the world literature. This infrequent extracranial metastasis may be due to the fact that patients do not live long enough to manifest metastases or result from the fact that brain tissue has some structural differences from other tissues in the body. This tumor can be easily mistaken for other anaplastic tumors like malignant melanoma, malignant lymphoma, or anaplastic carcinoma. Positive glial fibrillary acidic (GFA) protein stain (an immunoperoxidase stain) of this metastatic tumor can eliminate all other time consuming, expensive, and exhausting procedures for the patient.
本文报告了一例罕见的多形性胶质母细胞瘤转移至颈部淋巴结的病例。尽管肿瘤行为极具侵袭性，但脑内多形性胶质母细胞瘤的颅外转移却很罕见。世界文献中仅报道了少数病例。这种罕见的颅外转移可能是由于患者生存期不足以出现转移，或者是因为脑组织与身体其他组织存在一些结构差异。这种肿瘤很容易被误诊为其他间变性肿瘤，如恶性黑色素瘤、恶性淋巴瘤或间变性癌。该转移性肿瘤的胶质纤维酸性蛋白（GFA）染色阳性（一种免疫过氧化物酶染色）可避免对患者进行所有其他耗时、昂贵且费力的检查程序。
