Denis D, Burguière O, Burillon C
Hôpital La Timone, Marseille, France.
Invest Ophthalmol Vis Sci. 1998 Nov;39(12):2232-8.
To develop models for assessing the differential growth of the fetal face along its horizontal and vertical axes, as well as of the orbit and the eye.
Normal human fetuses (n = 205), whose gestational ages ranged from 15.5 to 41 weeks of amenorrhea, were examined. Orbitofacial parameters were as follows: outer canthal distance, inner canthal distance, palpebral fissure length, and oropalpebral distance. Ocular parameters were corneal diameter and axial length. Correlations were tested among all parameters. Linear and polynomial regression analyses of gestational age and the orbitofacial and ocular parameters were used to develop models of growth. Differential patterns of growth in the face were investigated.
The best correlation was found between palpebral fissure length and oropalpebral distance. The increase of each of the parameters studied could be accurately described by a linear model. Sex had no detectable effect on these parameters. Compared with the skull, the face had a more rapid growth along the vertical axis. The palpebral fissure developed more rapidly than the eye.
The parameters that were studied in the fetal face, orbit, and eye follow a roughly linear growth curve.
建立评估胎儿面部沿水平和垂直轴以及眼眶和眼球差异生长的模型。
检查了205例正常人类胎儿，其孕周范围为停经15.5至41周。眶面部参数如下：外眦距、内眦距、睑裂长度和口睑距。眼部参数为角膜直径和眼轴长度。对所有参数进行相关性检验。使用孕周与眶面部及眼部参数的线性和多项式回归分析来建立生长模型。研究面部生长的差异模式。
睑裂长度与口睑距之间的相关性最佳。所研究的每个参数的增加都可以用线性模型准确描述。性别对这些参数没有可检测到的影响。与颅骨相比，面部沿垂直轴生长更快。睑裂比眼球发育更快。
在胎儿面部、眼眶和眼球中研究的参数遵循大致线性的生长曲线。
