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The S100B protein inhibits phosphorylation of GFAP and vimentin in a cytoskeletal fraction from immature rat hippocampus.

作者信息

Ziegler D R, Innocente C E, Leal R B, Rodnight R, Gonçalves C A

机构信息

Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brazil.

出版信息

Neurochem Res. 1998 Oct;23(10):1259-63. doi: 10.1023/a:1020740115790.

DOI:10.1023/a:1020740115790
PMID:9804281
Abstract

The S100B protein belongs to a family of small Ca2+-binding proteins involved in several functions including cytoskeletal reorganization. The effect of S 100B on protein phosphorylation was investigated in a cytoskeletal fraction prepared from immature rat hippocampus. An inhibitory effect of 5 microM S100B on total protein phosphorylation, ranging from 25% to 40%, was observed in the presence of Ca2+ alone, Ca2+ plus calmodulin or Ca2+ plus cAMP. Analysis by two dimensional electrophoresis revealed a Ca2+/calmodulin-dependent and a Ca2+/cAMP-dependent inhibitory effect of S100B, ranging from 62% to 67% of control, on the phosphorylation of the intermediate filament proteins glial fibrillary acidic protein (GFAP) and vimentin. The fact that S100B binds to the N-terminal domain of GFAP and that the two proteins are co-localized in astrocytes suggests a potential in vivo role for S100B in modulating the phosphorylation of intermediate filament proteins in glia.

摘要

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1
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2
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本文引用的文献

1
Calcium-dependent phosphorylation of glial fibrillary acidic protein (GFAP) in the rat hippocampus: a comparison of the kinase/phosphatase balance in immature and mature slices using tryptic phosphopeptide mapping.大鼠海马中胶质纤维酸性蛋白（GFAP）的钙依赖性磷酸化：使用胰蛋白酶磷酸肽图谱比较未成熟和成熟脑片的激酶/磷酸酶平衡。
Brain Res Dev Brain Res. 1997 Dec 19;104(1-2):1-10. doi: 10.1016/s0165-3806(97)00113-2.
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Control of the phosphorylation of the astrocyte marker glial fibrillary acidic protein (GFAP) in the immature rat hippocampus by glutamate and calcium ions: possible key factor in astrocytic plasticity.谷氨酸和钙离子对未成熟大鼠海马中星形胶质细胞标志物胶质纤维酸性蛋白（GFAP）磷酸化的调控：星形胶质细胞可塑性的可能关键因素。
Braz J Med Biol Res. 1997 Mar;30(3):325-38. doi: 10.1590/s0100-879x1997000300005.
3
酒精对女性而非男性星形胶质细胞功能的损害
Brain Pathol. 2016 Jul;26(4):433-51. doi: 10.1111/bpa.12276. Epub 2015 Jul 14.
4
Identification of differentially expressed genes in pituitary adenomas by integrating analysis of microarray data.通过微阵列数据的整合分析鉴定垂体腺瘤中差异表达的基因。
Int J Endocrinol. 2015;2015:164087. doi: 10.1155/2015/164087. Epub 2015 Jan 6.
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Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice.内皮型血管性血友病因子促进血脑屏障的柔韧性，并为小鼠提供对缺氧和癫痫的保护。
Arterioscler Thromb Vasc Biol. 2013 Sep;33(9):2112-20. doi: 10.1161/ATVBAHA.113.301362. Epub 2013 Jul 3.
6
Bergmann glial S100B activates myo-inositol monophosphatase 1 and Co-localizes to purkinje cell vacuoles in SCA1 transgenic mice.伯格曼神经胶质细胞的S100B激活肌醇单磷酸酶1，并与SCA1转基因小鼠的浦肯野细胞液泡共定位。
Cerebellum. 2009 Sep;8(3):231-44. doi: 10.1007/s12311-009-0125-5. Epub 2009 Jul 11.
7
S100B-mediated inhibition of the phosphorylation of GFAP is prevented by TRTK-12.TRTK-12可防止S100B介导的GFAP磷酸化抑制。
Neurochem Res. 2004 Apr;29(4):735-40. doi: 10.1023/b:nere.0000018844.51009.40.
S-100 (alpha and beta) binding peptide (TRTK-12) blocks S-100/GFAP interaction: identification of a putative S-100 target epitope within the head domain of GFAP.S-100（α和β）结合肽（TRTK-12）阻断S-100/GFAP相互作用：在GFAP头部结构域内鉴定一个假定的S-100靶表位。
Biochim Biophys Acta. 1996 Oct 11;1313(3):258-67. doi: 10.1016/0167-4889(96)00098-5.
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Ca2+/S100 regulation of giant protein kinases.巨蛋白激酶的钙离子/ S100调节
Nature. 1996 Apr 18;380(6575):636-9. doi: 10.1038/380636a0.
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S-100 protein, but not calmodulin, binds to the glial fibrillary acidic protein and inhibits its polymerization in a Ca(2+)-dependent manner.
J Biol Chem. 1993 Jun 15;268(17):12669-74.
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Glial-derived S100b protein selectively inhibits recombinant beta protein kinase C (PKC) phosphorylation of neuron-specific protein F1/GAP43.神经胶质细胞衍生的S100b蛋白选择性抑制神经元特异性蛋白F1/GAP43的重组β蛋白激酶C（PKC）磷酸化。
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The endless story of the glial fibrillary acidic protein.胶质纤维酸性蛋白的无尽故事。
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The S-100: a protein family in search of a function.S-100：一个寻找功能的蛋白质家族。
Prog Neurobiol. 1995 May;46(1):71-82. doi: 10.1016/0301-0082(94)00062-m.
9
Effect of S-100 proteins and calmodulin on Ca2+-induced disassembly of brain microtubule proteins in vitro.S-100蛋白和钙调蛋白对体外钙诱导脑微管蛋白解聚的影响。
FEBS Lett. 1982 Oct 18;147(2):165-8. doi: 10.1016/0014-5793(82)81033-8.
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S-100-mediated inhibition of brain protein phosphorylation.
J Neurochem. 1983 Oct;41(4):1040-5. doi: 10.1111/j.1471-4159.1983.tb09048.x.