Rodríguez M D, Gámez R, Sánchez M, García H
Department of Toxicology, National Centre for Scientific Research, Havana, Cuba.
J Appl Toxicol. 1998 Sep-Oct;18(5):313-6. doi: 10.1002/(sici)1099-1263(1998090)18:5<313::aid-jat513>3.0.co;2-8.
D-002 is a mixture of higher aliphatic alcohols, primarily isolated and purified from beeswax, that has moderate anti-inflammatory and effective anti-ulcer activity. In the present study the developmental toxicity in Sprague-Dawley rats and New Zealand White rabbits was evaluated. Doses of 100, 320 and 1000 mg kg(-1) were administered once daily by gavage to pregnant females on gestation days 6-15 (rats) or 6-18 (rabbits). Reproductive indices were determined and foetuses were examined for external, visceral and skeletal malformations. There was no indication of embryotoxicity, fetotoxicity or teratogenicity in any of the treated groups. It is concluded that D-002 is devoid of teratogenic or embryotoxic effects in these strains.
D - 002是一种高级脂肪醇的混合物，主要从蜂蜡中分离纯化得到，具有中等抗炎和有效的抗溃疡活性。在本研究中，评估了其对斯普拉格 - 道利大鼠和新西兰白兔的发育毒性。在妊娠第6 - 15天（大鼠）或第6 - 18天（兔子），通过灌胃每天给怀孕的雌性动物一次100、320和1000 mg/kg(-1)的剂量。测定生殖指标，并检查胎儿的外部、内脏和骨骼畸形。在任何处理组中均未发现胚胎毒性、胎儿毒性或致畸性的迹象。得出的结论是，D - 002在这些品系中没有致畸或胚胎毒性作用。
