Tucker A S, Matthews K L, Sharpe P T
Department of Craniofacial Development, Guy's, King's, and St. Thomas' School of Dentistry, Guy's Hospital, London SE1 9RT, UK.
Science. 1998 Nov 6;282(5391):1136-8. doi: 10.1126/science.282.5391.1136.
Mammalian dentitions are highly patterned, with different types of teeth positioned in different regions of the jaws. BMP4 is an early oral epithelial protein signal that directs odontogenic gene expression in mesenchyme cells of the developing mandibular arch. BMP4 was shown to inhibit expression of the homeobox gene Barx-1 and to restrict expression to the proximal, presumptive molar mesenchyme of mouse embryos at embryonic day 10. The inhibition of BMP signaling early in mandible development by the action of exogenous Noggin protein resulted in ectopic Barx-1 expression in the distal, presumptive incisor mesenchyme and a transformation of tooth identity from incisor to molar.
哺乳动物的牙列具有高度的模式化，不同类型的牙齿位于颌骨的不同区域。骨形态发生蛋白4（BMP4）是一种早期口腔上皮蛋白信号，可指导发育中的下颌弓间充质细胞中的牙源性基因表达。研究表明，BMP4可抑制同源框基因Barx-1的表达，并在胚胎第10天将其表达限制在小鼠胚胎近端的假定磨牙间充质中。通过外源性Noggin蛋白的作用在颌骨发育早期抑制BMP信号传导，导致Barx-1在远端假定切牙间充质中异位表达，以及牙齿身份从切牙转变为磨牙。
