Berthet B, Sugarbaker P H
Département de Chirurgie Générale et Digestive, Hôpital de la Timone, Marseille.
Ann Chir. 1998;52(7):607-11.
Local recurrence and prognosis of abdominopelvic sarcomas depend on complete resection of the primary malignancy. Peritoneal seeding of the tumor can be assessed by the size of the tumor and the number of abdominopelvic regions involved by sarcoma. Under these conditions, we analyzed 14 consecutive patients with primary sarcoma. Complete resection of the tumor was performed in 9 patients with peritoneal involvement less than or equal to 3 abdomino-pelvic regions and complete resection combined with perioperative intraperitoneal chemotherapy was performed for the last 5 patient with involvement of more than 3 abdomino-pelvic regions. Results shows that the median survival was 28 months and the survival for very large tumors treated with perioperative intraperitoneal chemotherapy was similar to survival for smaller tumors treated by resection only. These results suggest the efficacy of chemotherapy on the site of resection and argue in favour of the use of regional chemotherapy in an attempt to achieve long-term disease-free survival for primary sarcoma.
腹盆腔肉瘤的局部复发和预后取决于原发性恶性肿瘤的完整切除。肿瘤的腹膜种植可通过肿瘤大小和肉瘤累及的腹盆腔区域数量来评估。在这些条件下，我们分析了14例连续的原发性肉瘤患者。9例腹膜受累小于或等于3个腹盆腔区域的患者进行了肿瘤完整切除，最后5例受累超过3个腹盆腔区域的患者进行了完整切除并联合围手术期腹腔内化疗。结果显示，中位生存期为28个月，围手术期腹腔内化疗治疗的非常大的肿瘤的生存期与仅通过切除治疗的较小肿瘤的生存期相似。这些结果表明化疗在切除部位的疗效，并支持使用区域化疗以试图实现原发性肉瘤的长期无病生存。
