Oelerich M, Lentschig M G, Zunker P, Reimer P, Rummeny E J, Schuierer G
Institute of Clinical Radiology, University of Münster, Germany.
Neuroradiology. 1998 Sep;40(9):567-73. doi: 10.1007/s002340050645.
We compared the value of 3D time-of-flight (TOF) and phase-contrast (PC) MR angiography (MRA) for detection and grading of intracranial vascular steno-occlusive disease. Unenhanced 3D-TOF MRA and 3D-PC MRA (30-60 cm/s velocity encoding) were performed at the level of the circle of Willis in 18 patients, mean age 56 +/- 10 years. Postprocessed images using a maximum-intensity projection reconstruction with multiple targetted projections were analysed. A total of 126 vessels was assessed by PC MRA and 143 by TOF MRA, with digital subtraction angiography (DSA) in 15 patients and/or transcranial Doppler sonography (TCD) in 18 as a standard. Two blinded readers reviewed the MRA, DSA and TCD examinations retrospectively. On DSA and/or TCD the two observers found 32 and 28 steno-occlusive lesions. 3D-TOF MRA was more sensitive than 3D-PC MRA (87% and 86% vs. 65% and 60%) and had a higher negative predictive value (96% vs. 89%). Correct grading of stenoses was achieved in 78 % by 3D-TOF and 65% by 3D-PC MRA.
我们比较了三维时间飞跃（TOF）和相位对比（PC）磁共振血管造影（MRA）在检测颅内血管狭窄闭塞性疾病及对其进行分级方面的价值。对18例平均年龄为56±10岁的患者在 Willis 环水平进行了非增强三维TOF MRA和三维PC MRA（速度编码为30 - 60 cm/s）检查。使用具有多个靶向投影的最大强度投影重建对后处理图像进行分析。通过PC MRA评估了总共126条血管，通过TOF MRA评估了143条血管，以15例患者的数字减影血管造影（DSA）和/或18例患者的经颅多普勒超声（TCD）作为标准。两位盲法阅片者对MRA、DSA和TCD检查进行了回顾性分析。在DSA和/或TCD上，两位观察者发现了32处和28处狭窄闭塞性病变。三维TOF MRA比三维PC MRA更敏感（分别为87%和86% 对比 65%和60%），并且具有更高的阴性预测值（96%对比89%）。三维TOF MRA对狭窄的正确分级率为78%，三维PC MRA为65%。
