Olander K, Haik K G, Haik G M
Ann Ophthalmol. 1978 Jul;10(7):853-62.
Pterygium, a common source of morbidity throughout the world, may appear to be an innocuous, easily excised lesion, yet it plagues the ophthalmologist by its high rate of recurrence, ranging from 20% to 30% after simple excision. Beta irradiation has been used by ophthalmic surgeons for many years. Another method of stemming the high percentage of pterygium recurrence is through local application of thiotepa, a radiomimetic drug that inhibits rapidly proliferating cells. The following report is a review of the literature from 1960 to 1977 on the role of thiotepa in treatment of pterygium, with emphasis on the complications of thiotepa administration. The recurrence rate after topical postoperative use of thiotepa ranges from 0 to 8%, with disturbing variance in results, depending on each investigator's definition of "recurrence", the length of follow-up, the type of pterygium, and the number of patients. The main reported complication from thiotepa's use has been depigmentation of skin around several patients' eyes, sometimes precipitated by exposure to the sun's rays.
翼状胬肉是全球常见的致病变源，看似是一种无害且易于切除的病变，但因其高复发率（单纯切除后复发率在20%至30%之间）一直困扰着眼科医生。多年来眼科外科医生一直使用β射线照射。另一种降低翼状胬肉高复发率的方法是局部应用噻替派，这是一种抑制快速增殖细胞的拟放射性药物。以下报告是对1960年至1977年关于噻替派在翼状胬肉治疗中作用的文献综述，重点关注噻替派给药的并发症。噻替派术后局部使用后的复发率在0%至8%之间，结果差异令人不安，这取决于每位研究者对“复发”的定义、随访时间、翼状胬肉的类型以及患者数量。使用噻替派报告的主要并发症是数名患者眼部周围皮肤色素脱失，有时因暴露于阳光下而加剧。
