Melilli G A, Di Gesù G, Loizzi V, Di Gesù A, Carriero C, Corsano P, Ferreri R
Istituto di Clinica Ostetrica e Ginecologica II, Università degli Studi, Bari.
Minerva Ginecol. 1998 Jul-Aug;50(7-8):291-5.
To report and compare personal experience with international literature on uterine sarcomas.
17 cases of uterine sarcomas diagnosed during seven years in our Institute, have been clinically histopathologically, prognostically and therapeutically analyzed.
10 cases of LMS, 6 of MMT, and 1 of ESS have been found. Women affected were mostly 42 to 84 years old. Most of the youngest patients were affected by LMS, while the oldest by MMT. Almost all of them were in menopause and pluriparae. The symptomatology consisted mainly of vaginal bleeding (58.9%). The diagnosis was preoperative for MMT and ESS; in 8 cases it was adopted for stage I, surgery and RT for stage II, surgery, RT and chemotherapy for a woman of stage III, and for the last two surgery and chemotherapy. The patients of stage III and IV survived respectively 8 and 10 months; three patients in stage I still have a 5 years survival and the other are still in follow-up.
This work is a clinical contribution since the rarity of these neoplasms does not allow the standardization of a diagnostical and therapeutical iter and consequently the improvement of prognosis.
报告并比较本人关于子宫肉瘤的经验与国际文献。
对我院七年间诊断的17例子宫肉瘤患者进行临床、组织病理学、预后及治疗分析。
发现10例平滑肌肉瘤、6例恶性混合苗勒管肿瘤及1例子宫内膜间质肉瘤。患者年龄多在42至84岁。最年轻的患者多为平滑肌肉瘤，最年长的为恶性混合苗勒管肿瘤。几乎所有患者均处于绝经后且为经产妇。症状主要为阴道出血（58.9%）。恶性混合苗勒管肿瘤和子宫内膜间质肉瘤术前确诊；8例I期患者采用手术治疗，II期患者采用手术及放疗，1例III期患者采用手术、放疗及化疗，最后2例采用手术及化疗。III期和IV期患者分别存活8个月和10个月；3例I期患者存活5年，其他患者仍在随访中。
由于这些肿瘤罕见，无法标准化诊断和治疗流程，进而改善预后，因此本研究具有临床意义。
