新生儿糖皮质激素治疗对成年未治疗、地塞米松治疗或维生素D3治疗大鼠骨矿化的影响。

Effect of neonatal glucocorticoid treatment on bone mineralization of adult nontreated, dexamethasone-treated or vitamin D3-treated rats.

Karabélyos C, Horváth C, Holló I, Csaba G

Department of Genetics, Cell and Immunobiology, Semmelweis University of Medicine, Budapest, Hungary.

Gen Pharmacol. 1998 Nov;31(5):789-91. doi: 10.1016/s0306-3623(98)00093-7.

Abstract

Single neonatal dexamethasone (DEX) treatment significantly decreased the body weights of 5-month old male rats. There was no significant difference in females. 2. Bone mineral density (BMD) of neonatally DEX-treated male rats and bone mineral content (BMC) of double DEX-treated (neonatally and in adult age) males were reduced. 3. BMD and BMC calculated to body weight were highly significantly increased after neonatal or double DEX treatment in males. In females only BMC/body weight was elevated after double DEX treatment. 4. Adult vitamin D treatment completely compensated for the changes caused by single or double DEX treatment. 5. The results call attention to the imprinting effects of neonatal glucocorticoid treatment, which were manifested in changes of body weight and bone mineral mass. At the same time the gender-dependence of this phenomenon was demonstrated.

摘要

单次新生期地塞米松（DEX）治疗显著降低了5月龄雄性大鼠的体重。雌性大鼠体重无显著差异。2. 新生期接受DEX治疗的雄性大鼠的骨密度（BMD）和接受双重DEX治疗（新生期和成年期）的雄性大鼠的骨矿物质含量（BMC）降低。3. 新生期或双重DEX治疗后，雄性大鼠按体重计算的BMD和BMC显著升高。雌性大鼠仅在双重DEX治疗后BMC/体重升高。4. 成年期维生素D治疗完全补偿了单次或双重DEX治疗引起的变化。5. 研究结果提醒人们注意新生期糖皮质激素治疗的印记效应，其表现为体重和骨矿物质质量的变化。同时证明了该现象的性别依赖性。