对双氯芬酸的迟发型超敏反应：两例报告。
Delayed hypersensitivity to diclofenac: a report on two cases.
作者信息
Romano A, Quaratino D, Papa G, Di Fonso M, Artesani M C, Venuti A
机构信息
Department of Internal Medicine and Geriatrics, UCSC-Allergy Unit, C.I. Columbus, Italy.
出版信息
Ann Allergy Asthma Immunol. 1998 Oct;81(4):373-5. doi: 10.1016/s1081-1206(10)63131-6.
BACKGROUND
Although skin reactions have been reported during use of diclofenac, a nonsteroidal anti-inflammatory drug, immunopathogenic mechanisms have been demonstrated in only a few cases.
METHODS
We administered skin and patch tests to two subjects who had developed maculopapular rashes respectively 48 and 72 hours after initiation of treatment with diclofenac.
RESULTS
In both cases, prick and intradermal tests with the drug were negative at 20 minutes, but 24 hours later an erythematous infiltrate had appeared at the intradermal test site. Patch tests with diclofenac were also positive at 48 and 72 hours.
CONCLUSIONS
The features of both these cases are suggestive of delayed hypersensitivity to diclofenac. Delayed-reading intradermal and patch tests may be a simple and effective means of diagnosing reactions of this type.
背景
尽管在使用非甾体抗炎药双氯芬酸期间有皮肤反应的报道，但仅在少数病例中证实了免疫致病机制。
方法
我们对两名分别在开始使用双氯芬酸治疗48小时和72小时后出现斑丘疹的受试者进行了皮肤和斑贴试验。
结果
在这两个病例中，用药后的点刺试验和皮内试验在20分钟时均为阴性，但24小时后皮内试验部位出现了红斑浸润。双氯芬酸斑贴试验在48小时和72小时时也呈阳性。
结论
这两个病例的特征提示对双氯芬酸存在迟发型超敏反应。延迟观察皮内试验和斑贴试验可能是诊断此类反应的一种简单有效的方法。
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