Medina F, Siddiqui A, Scimonelli T, Fenske C, Wilson C A, Celis M E
Cátedra de Fisiología Nacional, Facultad de Ciencias Químicas, Universidad de Córdoba, Argentina.
Peptides. 1998;19(8):1309-16. doi: 10.1016/s0196-9781(98)00093-x.
Estradiol benzoate (10 microg EB) given to ovariectomized-adrenalectomized rats induced sexual receptivity in half the animals and increased alpha-MSH in the preoptic area, ventromedial nucleus (VMN) and arcuate nucleus (ARC), in all the animals, although levels were significantly higher in the VMN and ARC of the receptive (R) subgroup. EB also raised levels of beta-endorphin in the VMN and ARC in the R rats only. POMC expression was not altered. EB did not affect alphaMSH in extra-hypothalamic areas, but addition of progesterone, raised levels in the septum, amygdala, hippocampus and caudate putamen. Only in the VMN, ARC and septum were the steroid-induced increases correlated with onset of sexual behavior.
给去卵巢-肾上腺切除的大鼠注射苯甲酸雌二醇（10微克EB），半数动物出现性接受能力，所有动物视前区、腹内侧核（VMN）和弓状核（ARC）中的α-促黑素（α-MSH）均增加，不过在有性接受能力（R）亚组的VMN和ARC中，其水平显著更高。EB仅使R组大鼠VMN和ARC中的β-内啡肽水平升高。促肾上腺皮质激素原（POMC）表达未改变。EB不影响下丘脑外区域的α-MSH，但添加孕酮后，隔区、杏仁核、海马体和尾状壳核中的水平升高。仅在VMN、ARC和隔区，类固醇诱导的增加与性行为的开始相关。
