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[联合干预措施:白内障与青光眼文献综述]

[Combined interventions: cataract and glaucoma review of the literature].

作者信息

Detry-Morel M

机构信息

Service d'Ophtalmologie, Cliniques Universitaires St. Luc, Bruxelles.

出版信息

Bull Soc Belge Ophtalmol. 1998;268:45-60.

PMID:9810083
Abstract

The combined surgical treatment of cataract and glaucoma has a long and controversial history. It changed dramatically over these two last decades with the technologic advances of both cataract and glaucoma surgery which have enabled to minimize the incidence and severity of complications and greatly influenced indications for combined surgery. During the 80's, extensive studies have shown the efficacy of combined trabeculectomy with extracapsular cataract extraction (ECCE) and posterior chamber lens implantation in patients with coexisting cataract and glaucoma. Small-incision cataract surgery by phacoemulsification with foldable introcular lenses have shortly replaced the ECCE in the beginning of the 1990's and have been, with pharmacologic modulation of wound healing for glaucoma filtering surgery, the most important factors which have contributed to a higher success rate and the actual relative safety of combined procedures. As compared to cataract extraction alone, the combined procedures offer better protection against the risk of early postoperative intraocular pressure increase, as well as the hope of better long-term intraocular pressure control. Although long-term intraocular pressure control has not been as predictable with combined surgery as in the two-stage approach, the recent use of antimetabolites (such as Mitomycin C) appeared to have improved early filtration success significantly. Conversely, combined operations tend to have a larger postoperative rate of complications than in cataract extraction alone. Having regard to the large variations in methods of patients selection, procedures evaluation, and criteria for success among the different authors, we will summarize the functional results, short and long-term intraocular pressure control and complications following combined procedures.

摘要

白内障与青光眼的联合手术治疗有着悠久且颇具争议的历史。在过去二十年中,随着白内障和青光眼手术技术的进步,这一情况发生了巨大变化。这些技术进步能够将并发症的发生率和严重程度降至最低,并对联合手术的适应症产生了重大影响。在20世纪80年代,大量研究表明,对于同时患有白内障和青光眼的患者,小梁切除术联合白内障囊外摘除术(ECCE)及后房型人工晶状体植入术具有疗效。20世纪90年代初,超声乳化白内障小切口手术及可折叠人工晶状体很快取代了ECCE,并且通过对青光眼滤过手术伤口愈合进行药物调节,这些成为提高联合手术成功率及实际相对安全性的最重要因素。与单纯白内障摘除术相比,联合手术能更好地预防术后早期眼压升高的风险,也带来了更好地长期控制眼压的希望。尽管联合手术对眼压的长期控制不如两阶段手术那样可预测,但近期使用抗代谢药物(如丝裂霉素C)似乎显著提高了早期滤过成功率。相反,联合手术的术后并发症发生率往往比单纯白内障摘除术更高。鉴于不同作者在患者选择方法、手术评估及成功标准方面存在很大差异,我们将总结联合手术后的功能结果、短期和长期眼压控制情况以及并发症。

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