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[测定肌红蛋白、肌酸磷酸激酶MB同工酶、乳酸脱氢酶和天门冬氨酸氨基转移酶在急性心肌梗死诊断中的应用价值]

[The usefulness of determining myoglobin, creatine phosphokinase MB isoenzyme, lactate dehydrogenase and aspartate aminotransferase in the diagnosis of acute myocardial infarct].

作者信息

Juárez U, Trejo W, Whente M, Contreras G, Cárdenas M, Reyes P A

机构信息

Unidad Coronaria, Instituto Nacional de Cardiología Ignacio Chávez, México, D.F.

出版信息

Arch Inst Cardiol Mex. 1998 May-Jun;68(3):214-7.

PMID:9810342
Abstract

Diagnosis of acute myocardial infarction is made with the aid of biomarkers such as structural myocardial proteins, myoglobin (MG) or specific enzymes, creatine phosphokinase isoenzyme MB (CK-MB) or non specific enzymes, lactic dehydrogenase (DHL) and aspartate aminotransferase (AST). We found good sensitivity (71%-50%), specificity (85%-100%) and predictive values (Pos. 77%-100%, Neg. 82%-72%) for Mg and CK-MB, supporting their clinical usefulness. In contrast DHL and AST were not clinically useful for early diagnosis.

摘要

急性心肌梗死的诊断借助生物标志物进行,如心肌结构蛋白、肌红蛋白(MG)或特定酶,肌酸磷酸激酶同工酶MB(CK-MB)或非特异性酶,乳酸脱氢酶(DHL)和天冬氨酸转氨酶(AST)。我们发现Mg和CK-MB具有良好的敏感性(71%-50%)、特异性(85%-100%)和预测值(阳性77%-100%,阴性82%-72%),支持它们的临床实用性。相比之下,DHL和AST对早期诊断无临床实用性。

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