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[感染性心内膜炎的神经系统并发症]

[The neurological complications of infectious endocarditis].

作者信息

Arauz-Góngora A A, Souta-Meiriño C A, Cotter-Lemus L E, Guzmán-Rodríguez C, Méndez-Domínguez A

机构信息

Departamento de Neurología, Instituto Nacional de Cardiología Ignacio Chávez INCICH. Juan Badiano No. 1., México, D.F.

出版信息

Arch Inst Cardiol Mex. 1998 Jul-Aug;68(4):328-32.

PMID:9810370
Abstract

We review the neurologic complications of 131 episodes of infective endocarditis, and the influences of some factors that are considered risk factors at its presentation, like the presence of vegetations detected by echocardiography, type and location of involved valve, or bacterial culture. Neurologic complications occurred in 28 patients (21.4%), 4 of them were excluded because of the absence of neuroimaging studies. In 21 patients the underlying cardiac pathology was valve disease and in the remaining 3 patients was congenital heart disease. 11 patients had native valve endocarditis and 10 prosthetic valve endocarditis. The cultured bacteria were Streptococcus viridans in 8 cases and Staphylococcus aureus in 7. The most frequent complication was cerebrovascular with incidence of cerebral embolism, and intracerebral hemorrhage of 62.5% and 8.3% respectively. Echocardiographic evidence of vegetation was seen in 18 patients, and cerebral embolism were noted in 12. Death occurred in 29% of patients with neurologic complications and 27% without. Two of nine patients who underwent open-heat surgery died. We conclude that there is no difference in the incidence of neurologic complications between mitral and aortic valve groups, neither when comparing native and prosthetic valve groups. Open-heart surgery does not increase mortality in this group of patients.

摘要

我们回顾了131例感染性心内膜炎的神经系统并发症,以及一些在发病时被视为危险因素的因素的影响,如超声心动图检测到的赘生物的存在、受累瓣膜的类型和位置或细菌培养。28例患者(21.4%)出现神经系统并发症,其中4例因未进行神经影像学检查而被排除。21例患者的潜在心脏病理为瓣膜病,其余3例为先天性心脏病。11例为自体瓣膜心内膜炎,10例为人工瓣膜心内膜炎。培养出的细菌8例为草绿色链球菌,7例为金黄色葡萄球菌。最常见的并发症是脑血管并发症,脑栓塞和脑出血的发生率分别为62.5%和8.3%。18例患者有超声心动图证据显示赘生物,其中12例出现脑栓塞。出现神经系统并发症的患者中有29%死亡,未出现神经系统并发症的患者中有27%死亡。接受心脏直视手术的9例患者中有2例死亡。我们得出结论,二尖瓣组和主动脉瓣组之间神经系统并发症的发生率没有差异,比较自体瓣膜组和人工瓣膜组时也没有差异。心脏直视手术不会增加这类患者的死亡率。

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