尼日利亚拉各斯献血者及淋巴系统恶性肿瘤患者中人类嗜T淋巴细胞病毒1型（HTLV-1）和艾滋病毒感染的血清学流行率研究
Seroprevalence study of HTLV-1 and HIV infection in blood donors and patients with lymphoid malignancies in Lagos, Nigeria.
作者信息
Analo H I, Akanmu A S, Akinsete I, Njoku O S, Okany C C
机构信息
Department of Haematology and Blood Transfusion, College of Medicine, University of Lagos, Nigeria.
出版信息
Cent Afr J Med. 1998 May;44(5):130-4.
OBJECTIVE
To document the seroprevalence of HTLV-1 and HIV in blood donors and in patients with lymphoma and leukaemia in Lagos metropolis.
DESIGN
Cross sectional.
SETTING
The Lagos University Teaching Hospital (LUTH) and General Hospital, Lagos (GH).
SUBJECTS
406 apparently healthy voluntary blood donors from the LUTH and GH and 30 patients [20 patients with histological diagnosis of Non-Hodgkin's Lymphoma (NHL) and 10 patients with diagnosis of Chronic Lymphocytic Leukaemia (CLL)] were recruited at LUTH.
MAIN OUTCOME MEASURES
HTLV-1 and HIV-1 seroprevalence.
RESULTS
Out of 406 donors, three (0.7%) were positive for HTLV-1 and 20 (4.9%) were positive for HIV-1. None of the 30 patients with NHL or CLL were positive for HTLV-1. Five of NHL patients were positive for HIV-1.
CONCLUSION
HTLV-1 seroprevalence is low among Lagos donors. Routine screening of donors for this virus will not be cost effective. NHL is one of the AIDS related malignancies which has been documented in this study.
目的
记录拉各斯市献血者以及淋巴瘤和白血病患者中人类嗜T淋巴细胞病毒1型（HTLV-1）和人类免疫缺陷病毒（HIV）的血清流行率。
设计
横断面研究。
地点
拉各斯大学教学医院（LUTH）和拉各斯综合医院（GH）。
研究对象
从LUTH招募了406名来自LUTH和GH的貌似健康的自愿献血者以及30名患者[20名经组织学诊断为非霍奇金淋巴瘤（NHL）的患者和10名诊断为慢性淋巴细胞白血病（CLL）的患者]。
主要观察指标
HTLV-1和HIV-1血清流行率。
结果
在406名献血者中，3人（0.7%）HTLV-1呈阳性，20人（4.9%）HIV-1呈阳性。30名NHL或CLL患者中无人HTLV-1呈阳性。5名NHL患者HIV-1呈阳性。
结论
拉各斯献血者中HTLV-1血清流行率较低。对献血者进行该病毒的常规筛查不具有成本效益。NHL是本研究中记录的与艾滋病相关的恶性肿瘤之一。
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