Jiménez-Jiménez F J, Ortí-Pareja M, Molina-Arjona J A
Sección de Neurología, Hospital Príncipe de Asturias, Universidad de Alcalá de Henares, España.
Rev Neurol. 1998 Apr;26 Suppl 1:S112-7.
There are many data suggesting the possible role of oxidative reactions mediated by free radicals in neurodegenerative disease. Because the mitochondrial respiratory chain exerts a protective role against these reactions, its dysfunction could contribute to 'oxidative stress'. There have been described alterations of the mitochondrial respiratory chain and mitochondrial genome in several neurodegenerative diseases, such as in Parkinson's, Alzheimer's and Huntington's diseases. This article focuses on a review of the current knowledge regarding this issue.
有许多数据表明自由基介导的氧化反应在神经退行性疾病中可能发挥的作用。由于线粒体呼吸链对这些反应具有保护作用，其功能障碍可能导致“氧化应激”。在几种神经退行性疾病中，如帕金森病、阿尔茨海默病和亨廷顿病，已经发现线粒体呼吸链和线粒体基因组存在改变。本文重点综述了关于这一问题的现有知识。
