Asahara T, Dohi K, Katayama K, Itamoto T, Okamoto Y, Nakahara H, Ono E, Sugino K, Marubayashi S, Yahata H, Kitamoto M, Nakanishi T, Azuma K, Ito K, Shimamoto F
Second Department of Surgery, Hiroshima University School of Medicine, Japan.
Hiroshima J Med Sci. 1998 Sep;47(3):99-104.
A retrospective analysis of clinical and pathological factors was performed on 132 surgical cases with solitary-nodule type HCC in our hospital. The overall cancer-free survival rates after 1, 3 and 5 years were 82.2%, 42.3% and 26.5%, respectively. With univariate analysis, the significant prognostic factors for survival were tumor size, cancer cell infiltration of the fibrous capsule of the tumor (fc-inf), invasion into portal vein (vp), and intrahepatic metastasis (im), while significant prognostic factors for non-recurrence were tumor size, fc-inf, vp, im, Edmondson-Steiner's classification and perioperative blood transfusion. With multivariate analysis for recurrence, significant factors were vp, clinical stage (CS), and perioperative blood transfusion. Therefore, prognostic factors for long-term survival in surgical cases of HCC are thought to be good hepatic function, absence of portal invasion, and avoidance of perioperative blood transfusion if possible.
