Park S W, Park H K, Hong M K, Lee S G, Lee I S, Kim J W, Lee C W, Kim J J, Park S J
Department of Internal Medicine, College of Medicine, University of Ulsan, Asan Medical Center, Seoul, Korea.
J Korean Med Sci. 1998 Oct;13(5):483-7. doi: 10.3346/jkms.1998.13.5.483.
Balloon angioplasty of ostial left anterior descending coronary artery (LAD) lesions has been associated with a high rate of acute complications and late restenosis. Recently, coronary stenting has been proposed as an effective treatment modality for ostial LAD lesions. To evaluate the effects of stent design on the development of late restenosis, we retrospectively analyzed the efficacy of slotted-tube stent implantation (40 patients, Palmaz-Schatz stent) and coil stent implantation (15 patients, tantalum Cordis stent) of ostial LAD stenosis. Six-month angiographic follow-up data were obtained in 31 patients (82%) with slotted-tube stent implantation and 12 patients (86%) with coil stent implantation. Angiographic restenosis was defined as > or =50% diameter stenosis. The angiographic restenosis rate was significantly lower in slotted-tube stent implantation (32%) than in coil stent implantation (67%) (p<0.05). Target lesion revascularization rate of slotted tube stent implantation was significantly lower (26%) than that of coil stent implantation (57%) (p<0.05). Coil stent implantation of ostial left anterior descending artery lesions was associated with higher late restenosis compared with slotted tube stent implantation. In conclusion, slotted-tube stent implantation might be considered to improve late clinical outcomes of ostial LAD lesions.
左前降支冠状动脉(LAD)开口处病变的球囊血管成形术与较高的急性并发症发生率和晚期再狭窄率相关。最近,冠状动脉支架置入术已被提议作为治疗LAD开口处病变的一种有效治疗方式。为了评估支架设计对晚期再狭窄发生的影响,我们回顾性分析了LAD开口处狭窄的槽式管支架置入术(40例患者,Palmaz-Schatz支架)和线圈支架置入术(15例患者,钽制Cordis支架)的疗效。31例(82%)接受槽式管支架置入术的患者和12例(86%)接受线圈支架置入术的患者获得了6个月的血管造影随访数据。血管造影再狭窄定义为直径狭窄≥50%。槽式管支架置入术的血管造影再狭窄率(32%)显著低于线圈支架置入术(67%)(p<0.05)。槽式管支架置入术的靶病变血运重建率(26%)显著低于线圈支架置入术(57%)(p<0.05)。与槽式管支架置入术相比,LAD开口处病变的线圈支架置入术与更高的晚期再狭窄相关。总之,槽式管支架置入术可能被认为可改善LAD开口处病变的晚期临床结局。