Gizurarson S, Sigurdoardóttir M, Stanzeit B
Department of Pharmacy, University of Iceland, P.O. Box 7171, 127 Reykjavik, Iceland.
J Pharm Sci. 1998 Nov;87(11):1267-9. doi: 10.1021/js980092e.
The kinetics of antibody responses were analyzed in various mucosal membranes as well as in the blood and the spleen after intranasal vaccination of mice with diphtheria toxoid. The results show a selective increase in antibody response in the respiratory area and the vagina followed by the gastrointestinal tract, but not in the spleen. IgG and IgM showed an increase 7 days after revaccination, followed by a rapid decline. However, IgA peaked 3 days after revaccination and did not decline throughout the study.
在用白喉类毒素对小鼠进行鼻内接种后，分析了抗体反应在各种粘膜以及血液和脾脏中的动力学。结果显示，呼吸道和阴道的抗体反应选择性增加，其次是胃肠道，但脾脏中没有。再次接种后7天，IgG和IgM增加，随后迅速下降。然而，IgA在再次接种后3天达到峰值，并且在整个研究过程中没有下降。
