Nuñez G, del Peso L
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor 48109, USA.
Curr Opin Neurobiol. 1998 Oct;8(5):613-8. doi: 10.1016/s0959-4388(98)80089-5.
The survival of cells in multicellular organisms requires continuous stimulation from the extracellular environment. The phosphatidylinositol-3' kinase/Akt signaling cascade has been identified as a critical pathway for the transduction of extracellular survival signals. The finding that the pro-apoptotic protein BAD is a substrate of Akt/PKB has provided the first link between extracellular survival signals and the apoptotic machinery.
多细胞生物中细胞的存活需要细胞外环境的持续刺激。磷脂酰肌醇-3'激酶/Akt信号级联已被确定为细胞外存活信号转导的关键途径。促凋亡蛋白BAD是Akt/PKB的底物这一发现，首次在细胞外存活信号与凋亡机制之间建立了联系。
