Jin Y L, Wang H Z, Gu H
Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing.
Zhonghua Liu Xing Bing Xue Za Zhi. 1997 Feb;18(1):40-2.
Using two interrelated observation indices--chromosomal aberration and micronucleus analysis in peripheral blood lymphocytes to reflect damages of genetic material, were used to observe the status of genetic material damage in male smokers at the same time. The results showed that there were significant increases in hyperpolid cell rate, chromatid and chromosome aberration rates, total aberant cell rate and frequency of micronucleated cells as well as micronucleus in smoking group when compared to non-smoking group. This findings showed that cigarette smoking is one of the important mutagenic factors which caused damage to human genetic materials.
利用两个相互关联的观察指标——外周血淋巴细胞中的染色体畸变和微核分析来反映遗传物质的损伤，同时观察男性吸烟者遗传物质损伤状况。结果显示，与非吸烟组相比，吸烟组的超倍体细胞率、染色单体和染色体畸变率、总畸变细胞率以及微核细胞频率和微核均显著增加。这一结果表明，吸烟是导致人类遗传物质损伤的重要诱变因素之一。
