Chen L, Liu W
Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan.
J Tongji Med Univ. 1997;17(3):144-6. doi: 10.1007/BF02888289.
Urinary epidermal growth factor (EGF) excretion in normal newborn as well as neonates with asphyxia was investigated by using radioimmunoassay, and serum creatinine (Scr) levels determined at the same time. The results showed that in severe asphyxia group the ratio of urinary EGF to urinary creatinine (Cr) (EGF/Cr), an index reflecting EGF excretion, was decreased on the first day (P < 0.05) and reached the lowest level on the third day (P < 0.01). However, EGF/Cr values were decreased only on the third day in neonates with mild asphyxia (P < 0.05). On the seventh day, EGF/Cr values of neonates with asphyxia rose to normal. There were a negative correlation between urinary EGF/Cr and Scr. It is suggested that EGF may play a role in the repair of acute renal injury after asphyxia and the detection of urinary EGF concentration is useful in the judgment of severity of renal injury and in the evaluation of the recovery of renal tubule after injury.
采用放射免疫分析法对正常新生儿及窒息新生儿的尿表皮生长因子（EGF）排泄情况进行了研究，并同时测定了血清肌酐（Scr）水平。结果显示，在重度窒息组，反映EGF排泄的指标尿EGF与尿肌酐（Cr）的比值（EGF/Cr）在第1天降低（P<0.05），并在第3天降至最低水平（P<0.01）。然而，轻度窒息新生儿仅在第3天EGF/Cr值降低（P<0.05）。在第7天，窒息新生儿的EGF/Cr值升至正常。尿EGF/Cr与Scr之间呈负相关。提示EGF可能在窒息后急性肾损伤的修复中发挥作用，检测尿EGF浓度有助于判断肾损伤的严重程度及评估损伤后肾小管的恢复情况。
